New research indicates that patients who come off popular weight-loss injections like Mounjaro or Wegovy can put back on reduced body mass far faster than those who halt traditional diet and exercise programs.
Published data in a prominent medical journal points out that while obese people often shed substantial amounts of their body weight while using the jabs, the mass returns at an average rate of 0.8 kg per month upon discontinuation.
"People purchasing such treatments need to be aware of the risk of rapid weight regain when the treatment is stopped," stated expert Dr. Susan Jebb.
Such speed of regain means a reversion to starting weight within about one and a half years.
Comparing Treatments
The research, which reviewed dozens of studies involving thousands of participants, contrasted the outcomes of these new drugs with older methods.
The team note that individuals who lose weight through dieting generally have a less rapid creep back—approximately 100 grams monthly—post-intervention.
Understanding the Quick Regain
Doctors suggest the mechanism of the injections accounts for the heightened weight return.
These medications imitate a natural hormone called glucagon-like peptide-1, which controls appetite.
"Long-term administration of GLP-1 concentrations several times higher than the body's typical production might result in the body to produce less of its own natural GLP-1, and could lessen sensitivity to its effects," explained Dr. Adam Collins, a dietetics expert.
"Withdrawal of this hormone supplement means hunger is no longer kept in check, making overeating far more likely."
A Chronic Issue?
The NHS advise the injections for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts say that, given the likelihood of relapse, the treatment is often ongoing.
This perspective is supported by drug manufacturers, who note that the results "highlight the persistent character of excess weight," comparing it to managing diseases like diabetes.
Patient Testimonies
Individuals who have discontinued the medication report a intense return of appetite.
"It felt as if something that goes on and you're instantly extremely hungry," said one woman.
The struggle is compounded if patients have not established lasting dietary or behavioural changes during treatment.
Growing Interest
Survey data suggest that a significant number of people in the UK have tried these injections in the last 12 months, with interest continuing to grow.
- Use is greater among women than males.
- The middle-aged demographic shows the highest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
In conclusion, clinicians caution that while the jabs are potent tools for weight loss, they are not a permanent cure and maintained weight loss relies on combined lifestyle changes.
